Discover the pivotal moment in the transformation of meningioma, where cutting-edge nuclear imaging with 18F-FDG and 68Ga-DOTATOC unveils the aggressive shift from atypical to anaplastic metastatic tumors.
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Transformation From Atypical to Anaplastic Metastatic Meningioma: Evolutionary Turning Point Marked by Strong 18F-FDG Avidity and Uptake Collapse From 68GA-DOTATOC.
Morcet-Delattre et al., Clin Nucl Med 2023
DOI: 10.1097/RLU.0000000000004985
Novelty & Importance: This case report highlights a rare instance of a meningioma evolving from WHO grade II atypical to grade III anaplastic metastatic meningioma, with a focus on the diagnostic imaging transition captured by 68Ga-DOTATOC and 18F-FDG PET scans. The significance lies in demonstrating the potential of molecular imaging to detect changes in tumor grade with high sensitivity.
Contribution to Literature: While the use of 18F-FDG in grading meningiomas has been debated, this case provides evidence supporting its utility alongside 68Ga-DOTATOC in assessing tumor progression. The findings suggest that molecular imaging can offer a detailed staging perspective and may reflect the biological behavior of the tumor in relation to its grade.
Results: The imaging with 68Ga-DOTATOC and 18F-FDG successfully captured the transformation of the meningioma from a lower to a higher WHO grade, which was subsequently confirmed by histological analysis. The case underscores the dynamic nature of tumor imaging and its correlation with the tumor’s pathological evolution.