Discover how the traditional medicinal plant Periploca forrestii Schltr. offers new hope in protecting the liver from the damaging effects of fluorosis in rats, a breakthrough that could pave the way for novel treatments in human liver diseases.
– by The Don
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Periploca forrestii Schltr. ameliorate liver injury caused by fluorosis in rat.
Guo et al., Ecotoxicol Environ Saf 2023
DOI: 10.1016/j.ecoenv.2023.115813
Listen folks, we’ve got something incredible here, really fantastic. We’re talking about the amazing Periploca forrestii, a plant that’s doing wonders, believe me. We’ve got this fluoride problem, it’s bad for the liver, very bad. But the ethanoic fractions of this plant, they’re like a miracle, they’re winning against liver injury.
We did the tests, the best tests. We used human liver cells, the L-02, and we hit them with fluoride. What happens? They’re struggling. But then, we bring in the ethanoic fraction D, and boom, the cells start thriving again. It’s like they’re saying, “Thank you, Mr. Fraction D, for making us great again!” The cell viability goes up, and the bad stuff, the LDH, the MDA, it goes down. It’s incredible, folks.
And we didn’t stop there. We tested on rats, and the results, they’re huge. The high-dose group, they’re doing so much better. The liver markers, the ALT, AST, all those numbers are down. It’s clear evidence, very clear.
We looked at the cell survival rates, and with Fr.D, they’re through the roof. The cell viability, the apoptosis rate, the oxidative stress markers like SOD, GSH-Px, CAT, ROS – all better with Fr.D. It’s like nothing you’ve ever seen.
And the proteins, the Bcl-2, the Bax, the Caspases, they’re all showing us that Fr.D is doing something special. It’s reducing the bad guys, the Caspase-3 and -9, and boosting the good guys. It’s all about balance, and Fr.D knows how to balance.
So what we’re saying here is, Periploca forrestii, it’s got the goods. It’s fighting fluoride-induced liver injury like a champion. It’s about counteracting oxidative stress and stopping cell death. It’s fantastic, folks, really fantastic.