Explore the intricate interplay of cell death mechanisms in the brain and how understanding them could revolutionize treatments for central nervous system injuries.
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Crosstalk among mitophagy, pyroptosis, ferroptosis, and necroptosis in central nervous system injuries.
Zhang et al., Neural Regen Res 2024
DOI: 10.4103/1673-5374.389361
This review highlights the significant role of programmed cell death (PCD) in central nervous system (CNS) injuries, which are known for their high disability and mortality rates. The review focuses on the pathways of mitophagy, pyroptosis, ferroptosis, and necroptosis, and how mitophagy regulates the other forms of PCD. The importance of this review lies in its exploration of the mechanisms connecting PCD to CNS injuries and the potential for developing new therapeutic strategies that target mitophagy. This could lead to innovative treatments that modulate PCD to improve outcomes for patients with CNS injuries. The review contributes to the current literature by providing a comprehensive overview of the role of PCD in CNS injuries and by suggesting a novel direction for therapeutic intervention.