Discover the critical link between pediatric systemic lupus erythematosus and renal thrombotic microangiopathy, a complication that demands immediate attention for the well-being of our youngest patients.
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Renal Thrombotic Microangiopathy: A Complication of Paediatric Systemic Lupus Erythematosus That Requires Attention.
Kalita et al., Cureus 2023
DOI: 10.7759/cureus.48382
Summary of Renal Vascular Lesions in Pediatric SLE
What’s New: The case of a 10-year-old female with pediatric systemic lupus erythematosus (pSLE) highlights the occurrence of renal vascular lesions (VL), specifically thrombotic microangiopathy (TMA), which is not commonly reported or emphasized in pSLE patients.
Importance: This case underscores the need for awareness of renal VL in pSLE, as it affects diagnosis and management. The current ISN/RPS classification does not prioritize VL, which may lead to underreporting and overlooking these lesions in clinical practice.
Contribution to Literature: The report suggests that renal VL, like TMA, should be considered in the evaluation of lupus nephritis (LN) due to its therapeutic implications. The PLASMIC score, a tool for managing TMA, is highlighted as a potential guide for treatment in LN patients with TMA.
Case Details: The patient presented with class IV LN, malignant hypertension, and hypocomplementemia. The identification of TMA was crucial for her management, indicating that similar cases may benefit from a thorough investigation for VL.