Dive into the fascinating world of marine medicine with our latest blog post, “Purification and Characterization of a Glycoprotein from Sipunculus nudus and its Immune-Enhancing Activity to RAW 264.7 Macrophages”. Discover how this unique marine organism contributes to the advancement of immunology and potential therapeutic applications.
– by James
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Purification and characterization of a glycoprotein from Sipunculus nudus and its immune-enhancing activity to RAW 264.7 macrophages.
Lu et al., Food Res Int 2023
DOI: 10.1016/j.foodres.2023.113591
A new study investigates the immune-enhancing activity of a glycoprotein (SGP1) derived from Sipunculus nudus, an edible marine invertebrate used in traditional Chinese medicine. The glycoprotein, with a molecular mass of 9.26 kDa, was found to contain 92.8% protein and 3.1% saccharide. The saccharide components were primarily lyxose, xylose, and glucose. The protein structure was mainly β-sheet, and it shared a 28.3% sequence similarity with Myohemerythrin.
Significantly, SGP1 demonstrated immune-enhancing activity by promoting macrophage proliferation, enhancing phagocytic capacity, and stimulating the secretion of nitric oxide, interleukin-1β, tumor necrosis factor-α, and interleukin-6 via NF-κB pathways.
This novel glycoprotein could potentially be used in functional foods as an immunopotentiator for individuals with weakened immune systems. This research contributes to the understanding of the medicinal properties of marine invertebrates and their potential applications in health and nutrition.